Pharyngeal arch artery morphogenesis

Across TCGA patient cohorts, RNA activity of the Pharyngeal arch artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDNRA, CALCRL, and PCDH17, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pharyngeal arch artery morphogenesis activity versus EDNRA in MESO (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	EDNRA →	+2.002	+0.084	<.001	<.001	3	32
MESO	CALCRL →	+1.525	+0.087	<.001	<.001	3	30
KICH	PCDH17 →	+1.292	+0.043	<.001	<.001	3	29
MESO	MYCT1 →	+1.350	+0.072	<.001	<.001	3	29
THYM	CALD1 →	+1.857	+0.074	<.001	<.001	3	29
THYM	UACA →	+1.552	+0.078	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061626 vs EDNRA — MESO

Explore this scatter interactively →