Pharyngeal arch artery morphogenesis

Across TCGA patient cohorts, RNA activity of the Pharyngeal arch artery morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GUCY1B1, RAI14, and DAPK3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pharyngeal arch artery morphogenesis activity versus GUCY1B1 in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GUCY1B1 →	+0.607	+0.109	<.001	<.001	3	9
BRCA	RAI14 →	+0.334	+0.064	<.001	.001	3	9
UCEC	DAPK3 →	+0.377	+0.089	.002	.002	3	8
COAD	FMNL3 →	+0.419	+0.058	.001	.002	3	8
OV	GUCY1A1 →	+0.757	+0.089	<.001	<.001	3	8
OV	LAMA4 →	+0.498	+0.074	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061626 vs GUCY1B1 — OV

Explore this scatter interactively →