Pharyngeal arch artery morphogenesis

Across TCGA patient cohorts, RNA activity of the Pharyngeal arch artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFB2, OGFRP1, and SERPINA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pharyngeal arch artery morphogenesis activity versus TGFB2 in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TGFB2 →	+0.821	+0.256	<.001	<.001	3	5
LUAD	OGFRP1 →	-0.448	-0.608	<.001	.003	3	3
LUAD	SERPINA3 →	+0.790	+0.663	.002	.001	3	3
UCEC	NOX4 →	+0.598	+0.683	.003	.001	3	3
CCRCC	C7 →	+1.897	+0.394	<.001	<.001	3	3
CCRCC	KRT16 →	+0.371	+0.448	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061626 vs TGFB2 — BRCA

Explore this scatter interactively →