Pharyngeal arch artery morphogenesis

Across TCGA cell cohorts, RNA activity of the Pharyngeal arch artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR3F, TESMIN, and PAQR6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR3F grouped by Pharyngeal arch artery morphogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	POLR3F →	+0.518	+1.550	.003	.001	3	3
LIVER	TESMIN →	-2.313	-1.266	<.001	.004	2	4
LIVER	PAQR6 →	-1.411	-1.781	.003	<.001	3	3
LIVER	ALS2CL →	-2.266	-2.009	.009	<.001	3	3
BREAST	ASTN2 →	-0.829	-0.786	.005	.002	3	3
STOMACH	FAM214A →	-1.869	-1.125	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR3F by Pharyngeal arch artery morphogenesis activity — LIVER

Explore this box plot interactively →