Actin filament bundle organization

Across TCGA cell cohorts, RNA activity of the Actin filament bundle organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VCL, ZBTB43, and BMP8B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VCL grouped by Actin filament bundle organization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VCL →	+1.376	+0.553	.002	.008	3	3
KIDNEY	ZBTB43 →	+0.841	+1.299	.005	.001	3	3
STOMACH	BMP8B →	-1.268	-0.991	<.001	.005	3	3
STOMACH	KLRG1 →	-1.026	-1.787	.004	<.001	3	3
LIVER	ELAC2 →	-0.721	-0.994	.001	.002	2	4
LUNG_NSCLC_LUAD	EPOP →	-0.863	-0.711	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VCL by Actin filament bundle organization activity — BLOOD_Leukemia

Explore this box plot interactively →