Actin filament bundle organization

Across TCGA pan-cancer cohorts, RNA activity of the Actin filament bundle organization pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 166 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Actin filament bundle organization pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and CESC, show the opposite pattern, with higher activity associated with better survival.

HNSC, KIRP, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.361	0.193	<.001	86	view →
KIRP	OS	Median	All	0.892	0.968	.001	47	view →
LGG	OS	Tertile	All	0.694	0.865	<.001	41	view →
MESO	OS	Median	II,III,IV	0.284	0.497	.001	36	view →
LIHC	OS	Median	III,IV	0.407	0.722	<.001	34	view →
CESC	OS	Quartile	IV	0.956	0.275	.010	30	view →
LUAD	OS	Median	IV	0.522	0.823	.005	30	view →
ESCA	OS	Quartile	III,IV	0.720	0.335	.007	26	view →
SKCM	OS	Tertile	III,IV	0.965	0.692	.001	25	view →
ACC	OS	Quartile	II,III,IV	0.674	0.968	.003	24	view →
BRCA	DFS	Median	III,IV	0.544	0.434	.016	22	view →
UVM	OS	Median	III,IV	0.492	0.815	.011	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0061572–HNSC (DFS)

Open the HNSC breakdown →