Actin filament bundle organization

Across TCGA cell cohorts, RNA activity of the Actin filament bundle organization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIC1, MILR1, and NMT2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament bundle organization activity versus CLIC1 in LIVER (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CLIC1 →	+1.490	+0.464	.008	.005	2	7
BLOOD_Leukemia	MILR1 →	+1.554	+0.122	.002	.009	3	6
SOFT_TISSUE	NMT2 →	+1.688	+0.405	.002	.004	3	6
SOFT_TISSUE	PHLDA2 →	+4.374	+0.459	.005	.009	2	7
BREAST	PRKCA →	+1.985	+0.296	.008	.002	3	6
OVARY	INSYN2B →	+1.603	+0.376	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061572 vs CLIC1 — LIVER

Explore this scatter interactively →