Cranial ganglion development

Across TCGA patient cohorts, RNA activity of the Cranial ganglion development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PGM2L1, ALYREF, and HNRNPA2B1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial ganglion development activity versus PGM2L1 in LSCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PGM2L1 →	+0.706	+0.116	<.001	<.001	3	7
GBM	ALYREF →	-0.378	-0.176	<.001	<.001	3	6
OV	HNRNPA2B1 →	-0.224	-0.061	<.001	.004	3	6
GBM	SF3B2 →	-0.256	-0.126	<.001	.002	3	6
OV	ZKSCAN8_S193 →	-0.838	-0.069	.001	.002	3	6
GBM	FUS →	-0.430	-0.156	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061550 vs PGM2L1 — LSCC

Explore this scatter interactively →