Cranial ganglion development

Across TCGA patient cohorts, RNA activity of the Cranial ganglion development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP7, SSPN, and PTPN21, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial ganglion development activity versus IGFBP7 in OV (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IGFBP7 →	+0.690	+0.145	.005	.001	3	6
BRCA	SSPN →	+0.754	+0.167	.001	.001	3	5
BRCA	PTPN21 →	+0.780	+0.175	<.001	<.001	3	5
OV	NRP1 →	+1.019	+0.190	<.001	<.001	3	5
UCEC	KLHL3 →	+0.571	+0.238	.002	.006	3	5
BRCA	SRPX →	+1.037	+0.143	<.001	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061550 vs IGFBP7 — OV

Explore this scatter interactively →