Cranial ganglion development

Across TCGA cell cohorts, RNA activity of the Cranial ganglion development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN2AIPNL, BRSK2, and TOMM20, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial ganglion development activity versus CDKN2AIPNL in SKIN (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDKN2AIPNL →	-0.768	-1.129	.001	.004	3	4
LARGE_INTESTINE	BRSK2 →	-2.567	-0.199	.003	<.001	2	5
PANCREAS	TOMM20 →	-0.831	-1.484	.001	.003	3	4
LIVER	NMRK1 →	+1.703	+0.431	<.001	.002	3	3
LIVER	HAO2 →	+0.070	+0.543	.002	.005	3	3
LIVER	RPL6 →	-1.116	-0.547	.008	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061550 vs CDKN2AIPNL — SKIN

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