Sympathetic ganglion development

Across TCGA cell cohorts, RNA activity of the Sympathetic ganglion development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOAT1, ZC2HC1C, and PMP22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOAT1 grouped by Sympathetic ganglion development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SOAT1 →	-1.460	-1.385	<.001	<.001	3	5
BREAST	ZC2HC1C →	+0.677	+0.793	.002	.001	3	4
KIDNEY	PMP22 →	-2.127	-1.153	.005	.002	3	4
LARGE_INTESTINE	ACADS →	+0.943	+0.537	<.001	.002	3	4
OVARY	PTBP3 →	+0.629	+0.495	.008	.009	2	5
PANCREAS	GPX2 →	+5.029	+1.135	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOAT1 by Sympathetic ganglion development activity — PANCREAS

Explore this box plot interactively →