Hindgut development

Across TCGA patient cohorts, RNA activity of the Hindgut development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRP1, PCOLCE, and SRPX, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hindgut development activity versus LRP1 in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LRP1 →	+0.408	+0.060	.008	.004	3	8
OV	PCOLCE →	+0.713	+0.074	.002	.001	3	8
CCRCC	SRPX →	+1.162	+0.079	.003	.004	3	7
OV	THBS3 →	+0.680	+0.079	<.001	<.001	3	7
BRCA	TLN2 →	+0.527	+0.082	<.001	<.001	3	7
HNSC	HMCN1 →	+0.631	+0.082	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061525 vs LRP1 — OV

Explore this scatter interactively →