Cilium disassembly

Across TCGA patient cohorts, RNA activity of the Cilium disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC4, STXBP1, and TOM1L2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cilium disassembly activity versus SMC4 in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC4 →	+0.608	+0.103	<.001	<.001	3	6
UCEC	STXBP1 →	-0.513	-0.078	.003	.004	3	6
UCEC	TOM1L2 →	-0.235	-0.068	<.001	.002	3	6
UCEC	UTP15 →	+0.203	+0.084	<.001	<.001	3	6
UCEC	UTP4 →	+0.389	+0.123	<.001	<.001	3	6
LUAD	XPO5 →	+0.414	+0.073	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061523 vs SMC4 — GBM

Explore this scatter interactively →