Microglial cell proliferation

Across TCGA cell cohorts, RNA activity of the Microglial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF605, ZBTB24, and AKAP8L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF605 grouped by Microglial cell proliferation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZNF605 →	+0.700	+1.378	<.001	<.001	3	4
CNS	ZBTB24 →	+0.392	+1.174	.007	.001	3	3
CNS	AKAP8L →	+0.441	+0.838	<.001	.007	3	3
CNS	RREB1 →	+0.595	+1.233	.001	.002	3	3
CNS	SHPRH →	+0.433	+1.084	<.001	<.001	3	3
CNS	YEATS2 →	+0.407	+1.426	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF605 by Microglial cell proliferation activity — KIDNEY

Explore this box plot interactively →