Macrophage proliferation

Across TCGA patient cohorts, RNA activity of the Macrophage proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMOD1, CLMAT3, and SSPN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage proliferation activity versus LMOD1 in UCEC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LMOD1 →	+1.448	+0.197	<.001	<.001	3	6
GBM	CLMAT3 →	+0.457	+0.148	.003	.001	3	6
UCEC	SSPN →	+0.553	+0.129	<.001	.001	3	5
UCEC	MS4A2 →	+0.714	+0.164	.002	<.001	3	5
UCEC	TPSAB1 →	+0.994	+0.137	<.001	.006	3	5
BRCA	CCN5 →	+0.974	+0.178	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061517 vs LMOD1 — UCEC

Explore this scatter interactively →