Protein localization to cilium

Across TCGA patient cohorts, RNA activity of the Protein localization to cilium pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DRC3, OSCP1, and WDR19, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cilium activity versus DRC3 in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DRC3 →	+0.930	+0.714	<.001	<.001	3	6
HNSC	OSCP1 →	+0.550	+0.423	.001	<.001	3	5
BRCA	WDR19 →	+0.624	+0.556	<.001	.001	3	5
LUAD	CCDC114 →	+0.623	+0.647	.001	<.001	2	5
BRCA	CCDC148 →	+0.577	+0.596	<.001	<.001	3	4
BRCA	DYNLRB2 →	+0.869	+0.450	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061512 vs DRC3 — BRCA

Explore this scatter interactively →