Protein localization to cilium

Across TCGA cell cohorts, RNA activity of the Protein localization to cilium pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF385A, SLC27A2, and LRFN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF385A grouped by Protein localization to cilium-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF385A →	-1.133	-1.313	.008	<.001	3	4
BLOOD_Leukemia	SLC27A2 →	+2.133	+0.901	.002	.003	3	3
OVARY	LRFN3 →	-0.692	-0.766	.004	.008	2	4
OVARY	VGLL4 →	-0.778	-1.372	.002	<.001	3	3
OVARY	DCTN2 →	-0.417	-0.881	.001	.002	3	3
OVARY	HOXD8 →	-1.874	-1.540	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF385A by Protein localization to cilium activity — OESOPHAGUS

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