Protein localization to cilium

Across TCGA cell cohorts, RNA activity of the Protein localization to cilium pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IMP3, CCDC9B, and ICAM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cilium activity versus IMP3 in PANCREAS (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	IMP3 →	-0.600	-0.763	.002	<.001	3	4
LIVER	CCDC9B →	+3.015	+0.200	.008	.004	3	4
OESOPHAGUS	ICAM2 →	+2.565	+0.738	.007	.008	3	3
BLOOD_Lymphoma	RIPK3 →	+1.418	+0.225	<.001	.002	3	3
BLOOD_Leukemia	GSTO1 →	-0.536	-0.423	.004	.009	3	3
LIVER	SLC10A1 →	-0.046	-0.166	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061512 vs IMP3 — PANCREAS

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