T follicular helper cell differentiation

Across TCGA patient cohorts, RNA activity of the T follicular helper cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM64, NPIPB4, and TCEAL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T follicular helper cell differentiation activity versus TMEM64 in COAD (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMEM64 →	-0.844	-0.572	<.001	<.001	3	3
LSCC	NPIPB4 →	+0.378	+0.200	.003	.004	3	3
LSCC	TCEAL3 →	-0.382	-0.266	.002	<.001	3	3
PDAC	EIF4EBP2P2 →	+0.271	+0.258	.007	.001	3	3
CCRCC	RARS2 →	+0.254	+0.131	<.001	.002	3	3
CCRCC	HMGN4 →	+0.228	+0.201	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061470 vs TMEM64 — COAD

Explore this scatter interactively →