Protein localization to lysosome

Across TCGA patient cohorts, RNA activity of the Protein localization to lysosome pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC2, MCM7, and CDCA3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to lysosome activity versus DNAJC2 in HNSC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DNAJC2 →	-0.835	-0.212	.001	<.001	3	6
LUAD	MCM7 →	-0.643	-0.133	<.001	.006	3	6
UCEC	CDCA3 →	-0.578	-0.132	.006	.009	3	5
LUAD	CKS2 →	-0.814	-0.158	<.001	.001	3	5
BRCA	MYC →	-0.846	-0.167	<.001	<.001	3	5
LUAD	SKA1 →	-0.802	-0.154	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061462 vs DNAJC2 — HNSC

Explore this scatter interactively →