Trophoblast cell migration

Across TCGA cell cohorts, RNA activity of the Trophoblast cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRD3OS, HDAC9, and STK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRD3OS grouped by Trophoblast cell migration-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	BRD3OS →	+1.308	+0.823	<.001	.009	3	4
STOMACH	HDAC9 →	+3.539	+1.252	<.001	<.001	3	4
BREAST	STK3 →	+0.751	+0.869	.005	.003	3	4
UPPER_AERODIGESTIVE_TRACT	CLEC2B →	-1.900	-1.582	.006	.002	2	4
UPPER_AERODIGESTIVE_TRACT	KIF12 →	-0.688	-1.374	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	POLR2A →	-0.750	-1.586	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRD3OS by Trophoblast cell migration activity — LIVER

Explore this box plot interactively →