Connective tissue development

Across TCGA patient cohorts, RNA activity of the Connective tissue development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL_S795, CYGB, and FBLN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Connective tissue development activity versus VCL_S795 in BRCA (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VCL_S795 →	+0.637	+0.033	<.001	<.001	3	10
OV	CYGB →	+0.674	+0.034	<.001	<.001	3	10
OV	FBLN1 →	+0.917	+0.037	<.001	<.001	3	10
OV	HSPG2 →	+0.561	+0.041	<.001	<.001	3	10
CCRCC	IGFBP7 →	+0.642	+0.034	<.001	<.001	3	10
UCEC	KANK2 →	+0.731	+0.041	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061448 vs VCL_S795 — BRCA

Explore this scatter interactively →