Connective tissue development

Across TCGA cell cohorts, RNA activity of the Connective tissue development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGO1, PRTN3, and EIF5A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGO1 grouped by Connective tissue development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AGO1 →	+0.431	+0.705	<.001	<.001	3	4
CNS	PRTN3 →	-0.154	-0.733	.005	.008	3	3
SKIN	EIF5A2 →	+0.731	+0.973	.001	<.001	3	3
LIVER	MFSD8 →	+0.468	+0.214	.001	.002	3	3
LIVER	LAPTM4A →	+0.601	+0.257	.007	<.001	3	3
OVARY	NFKBIZ →	-1.987	-0.797	.008	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGO1 by Connective tissue development activity — SKIN

Explore this box plot interactively →