Renal system vasculature morphogenesis

Across TCGA cell cohorts, RNA activity of the Renal system vasculature morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEAK1, REEP6, and RUNX2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal system vasculature morphogenesis activity versus PEAK1 in BREAST (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PEAK1 →	+2.552	+1.650	.004	.006	3	4
KIDNEY	REEP6 →	-1.596	-1.482	.003	<.001	2	4
URINARY_TRACT	RUNX2 →	+2.810	+1.795	.006	.008	2	4
URINARY_TRACT	SHOX2 →	+2.465	+1.741	<.001	.001	2	4
LIVER	NMRK1 →	+1.759	+1.742	.009	<.001	2	4
SKIN	ARMCX3 →	+1.330	+1.910	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061438 vs PEAK1 — BREAST

Explore this scatter interactively →