Establishment of skin barrier

Across TCGA cell cohorts, RNA activity of the Establishment of skin barrier pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN2, ST14, and TMTC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of skin barrier activity versus CAPN2 in BLOOD_Lymphoma (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CAPN2 →	+5.363	+0.296	<.001	<.001	3	6
LUNG_NSCLC_LUSC	ST14 →	-5.037	-0.250	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	TMTC1 →	+1.909	+0.236	.008	.007	3	5
BLOOD_Lymphoma	ANXA4 →	+2.649	+0.275	.002	.003	3	5
BLOOD_Lymphoma	ATP6V0E1 →	+1.238	+0.286	<.001	.001	3	5
STOMACH	C1GALT1C1 →	+1.011	+0.331	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061436 vs CAPN2 — BLOOD_Lymphoma

Explore this scatter interactively →