Bone trabecula morphogenesis

Across TCGA patient cohorts, RNA activity of the Bone trabecula morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS3, C8A, and PCOLCE, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone trabecula morphogenesis activity versus THBS3 in UCEC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	THBS3 →	+0.547	+0.121	.001	<.001	3	9
BRCA	C8A →	+0.606	+0.055	.001	<.001	3	9
GBM	PCOLCE →	+1.158	+0.092	<.001	<.001	3	9
BRCA	CFH →	+0.653	+0.050	<.001	<.001	3	8
CCRCC	EMILIN1 →	+0.493	+0.066	.002	.004	3	8
COAD	SFRP2 →	+1.552	+0.049	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061430 vs THBS3 — UCEC

Explore this scatter interactively →