Bone trabecula morphogenesis

Across TCGA patient cohorts, RNA activity of the Bone trabecula morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC1A, TAL1, and PRELP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone trabecula morphogenesis activity versus CLEC1A in BRCA (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLEC1A →	+0.513	+0.492	<.001	.007	3	5
BRCA	TAL1 →	+0.467	+0.689	<.001	<.001	3	5
COAD	PRELP →	+1.271	+0.655	<.001	<.001	3	5
GBM	GNG7 →	+0.796	+0.150	<.001	<.001	3	5
OV	NR2F2-AS1 →	+0.301	+0.311	<.001	<.001	3	5
BRCA	TPTEP1 →	+0.744	+0.417	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061430 vs CLEC1A — BRCA

Explore this scatter interactively →