Regulation of extent of cell growth

Across TCGA cell cohorts, RNA activity of the Regulation of extent of cell growth pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAH5, LY6K, and STXBP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of extent of cell growth activity versus DNAH5 in PANCREAS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNAH5 →	+0.608	+0.193	.003	.002	3	6
LUNG_NSCLC_LUSC	LY6K →	+4.358	+0.248	<.001	.001	3	6
BLOOD_Lymphoma	STXBP3 →	+0.610	+0.187	<.001	.006	3	5
BLOOD_Leukemia	CEP72 →	+0.697	+0.232	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CLNS1A →	-1.490	-0.236	<.001	.001	3	5
LUNG_NSCLC_LUSC	GLG1 →	+1.342	+0.214	<.001	.004	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061387 vs DNAH5 — PANCREAS

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