Testosterone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Testosterone biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1_S1143, PRKG1_T517, and RBSN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Testosterone biosynthetic process activity versus TLN1_S1143 in UCEC (Pearson r = -0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TLN1_S1143 →	+1.638	+0.408	<.001	<.001	3	5
HNSC	PRKG1_T517 →	+1.482	+0.504	<.001	.002	2	6
UCEC	RBSN →	+0.223	+0.225	<.001	<.001	3	4
OV	KNG1_S332 →	+0.662	+0.204	<.001	<.001	3	4
UCEC	SRRM2_T1208 →	-0.354	-0.253	<.001	<.001	3	3
UCEC	EPN2_S426 →	+0.685	+0.290	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061370 vs TLN1_S1143 — UCEC

Explore this scatter interactively →