Cardiac conduction

Across TCGA patient cohorts, RNA activity of the Cardiac conduction pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, SYNPO, and SYNPO2_S363, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac conduction activity versus RSU1 in UCEC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RSU1 →	+0.383	+0.037	.001	.001	3	7
HNSC	SYNPO →	+0.410	+0.049	.001	<.001	3	7
UCEC	SYNPO2_S363 →	+0.888	+0.028	<.001	.006	3	7
GBM	COX7A1 →	+0.603	+0.044	.007	.001	3	7
BRCA	CNRIP1 →	+0.568	+0.031	<.001	<.001	3	7
PDAC	HGF →	+0.388	+0.023	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061337 vs RSU1 — UCEC

Explore this scatter interactively →