Cardiac conduction

Across TCGA patient cohorts, RNA activity of the Cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAI1, SGIP1, and MPZL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac conduction activity versus GNAI1 in CCRCC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GNAI1 →	+0.585	+0.728	<.001	.007	3	4
CCRCC	SGIP1 →	+0.845	+0.699	<.001	.001	3	4
BRCA	MPZL2 →	+0.748	+0.680	.004	.001	3	4
BRCA	GPR25 →	-0.286	-0.533	.004	.001	3	4
BRCA	HEPH →	+0.848	+0.746	<.001	<.001	3	4
PDAC	RAD9B →	-0.184	-0.329	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061337 vs GNAI1 — CCRCC

Explore this scatter interactively →