Cardiac conduction

Across TCGA cell cohorts, RNA activity of the Cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMS19, USP34, and TULP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MMS19 grouped by Cardiac conduction-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MMS19 →	+0.803	+1.173	<.001	<.001	3	4
CNS	USP34 →	+0.424	+0.856	.003	.003	3	4
CNS	TULP3 →	+0.478	+0.727	.003	.006	3	4
STOMACH	MRPL19 →	+0.891	+1.250	<.001	<.001	3	3
BLOOD_Leukemia	ZC3H10 →	+0.451	+0.858	.001	.002	3	3
LUNG_SCLC	PCGF6 →	+0.921	+1.184	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MMS19 by Cardiac conduction activity — LUNG_SCLC

Explore this box plot interactively →