Cardiac neural crest cell development involved in outflow tract morphogenesis

Across TCGA patient cohorts, RNA activity of the Cardiac neural crest cell development involved in outflow tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAG1, SYDE1, and EFNB3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac neural crest cell development involved in outflow tract morphogenesis activity versus JAG1 in LSCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	JAG1 →	+0.964	+0.416	.001	.009	3	3
LSCC	SYDE1 →	+0.757	+0.517	<.001	<.001	3	3
LSCC	EFNB3 →	+0.584	+0.624	.004	<.001	3	3
LSCC	PGF →	+0.567	+0.318	.003	.004	3	3
LSCC	TSHZ3 →	+0.572	+0.347	.001	.005	3	3
BRCA	TWIST1 →	+1.244	+0.606	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061309 vs JAG1 — LSCC

Explore this scatter interactively →