Cardiac neural crest cell differentiation involved in heart development

Across TCGA patient cohorts, RNA activity of the Cardiac neural crest cell differentiation involved in heart development pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA1, NID2, and FHL5, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac neural crest cell differentiation involved in heart development activity versus ITGA1 in THYM (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	ITGA1 →	+1.241	+0.081	<.001	<.001	3	27
THYM	NID2 →	+2.184	+0.080	<.001	<.001	3	27
KIRC	FHL5 →	+0.995	+0.058	<.001	<.001	3	26
TGCT	ADAMTS9 →	+1.733	+0.149	<.001	<.001	3	26
THYM	COL4A1 →	+1.613	+0.082	<.001	<.001	3	26
TGCT	FERMT2 →	+1.385	+0.136	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061307 vs ITGA1 — THYM

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