Cardiac neural crest cell differentiation involved in heart development

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac neural crest cell differentiation involved in heart development pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 16 member genes.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher Cardiac neural crest cell differentiation involved in heart development pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and HNSC, show the opposite pattern, with higher activity associated with better survival.

DLBC, LGG, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	IV	0.128	1.000	.017	15	view →
LGG	OS	Tertile	All	0.855	0.935	.002	15	view →
KIRC	OS	Tertile	All	0.893	0.833	.006	14	view →
HNSC	DFS	Tertile	IV	0.506	0.257	.010	12	view →
ACC	OS	Quartile	All	0.283	0.710	.019	12	view →
SKCM	DFS	Tertile	III,IV	0.316	0.513	.014	10	view →
READ	DFS	Quartile	IV	0.235	0.843	.005	9	view →
LUSC	OS	Tertile	All	0.725	0.796	.031	8	view →
MESO	OS	Quartile	All	0.241	0.440	.038	7	view →
UVM	DFS	Quartile	All	0.888	0.496	.026	6	view →
THYM	DFS	Median	II,III,IV	0.947	0.518	.005	6	view →
UCEC	DFS	Quartile	All	0.571	0.790	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0061307–DLBC (DFS)

Open the DLBC breakdown →