Cardiac neural crest cell differentiation involved in heart development

pathway activity — cross-omics
GO:0061307Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cardiac neural crest cell differentiation involved in heart development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAI14, CDC42EP1_S353, and MPRIP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac neural crest cell differentiation involved in heart development activity versus RAI14 in OV (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVRAI14 →+0.330+0.069<.001<.00139
LSCCCDC42EP1_S353 →+0.466+0.070<.001<.00139
LUADMPRIP →+0.302+0.108<.001<.00139
BRCAOLFML1 →+0.990+0.064<.001<.00139
OVTNS2 →+0.394+0.068<.001.00139
CCRCCVCL →+0.317+0.071<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061307 vs RAI14 — OV

Per-sample scatter of Cardiac neural crest cell differentiation involved in heart development activity vs RAI14 in OV.

Explore this scatter interactively →

Exploration