Cardiac neural crest cell differentiation involved in heart development

Across TCGA patient cohorts, RNA activity of the Cardiac neural crest cell differentiation involved in heart development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPAS1, CYGB, and RNU1-1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac neural crest cell differentiation involved in heart development activity versus EPAS1 in CCRCC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EPAS1 →	+0.664	+0.147	.008	.009	3	4
CCRCC	CYGB →	+0.657	+0.173	.004	.001	3	4
CCRCC	RNU1-1 →	+1.076	+0.186	.001	<.001	3	4
LUAD	MYOZ3 →	+0.246	+0.211	.006	.003	3	4
BRCA	THSD1 →	+0.540	+0.209	.004	.002	3	4
LUAD	SRPX →	+0.506	+0.179	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061307 vs EPAS1 — CCRCC

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