Establishment or maintenance of bipolar cell polarity

Across TCGA cell cohorts, RNA activity of the Establishment or maintenance of bipolar cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR5B, NNMT, and CBX5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR5B grouped by Establishment or maintenance of bipolar cell polarity-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WDR5B →	-0.751	-0.796	.002	.001	3	5
UPPER_AERODIGESTIVE_TRACT	NNMT →	+4.236	+0.434	.002	.009	3	4
OESOPHAGUS	CBX5 →	-1.032	-0.342	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	YIPF1 →	+0.878	+0.307	.004	.002	3	3
LUNG_SCLC	C17orf75 →	-0.910	-1.170	.002	.009	3	3
LUNG_SCLC	RNF157 →	-2.580	-1.196	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR5B by Establishment or maintenance of bipolar cell polarity activity — LARGE_INTESTINE

Explore this box plot interactively →