Regulation of mesonephros development

Across TCGA patient cohorts, RNA activity of the Regulation of mesonephros development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAU2, SIX1, and SIX1_S204, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mesonephros development activity versus STAU2 in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STAU2 →	+0.407	+0.075	.001	.007	3	6
UCEC	SIX1 →	+2.283	+0.197	<.001	.002	3	5
LSCC	SIX1_S204 →	+1.112	+0.112	<.001	<.001	3	5
UCEC	SIX4 →	+0.393	+0.120	.001	.001	3	5
LSCC	ZEB2 →	-0.302	-0.103	.003	.004	3	5
BRCA	DAB2 →	-0.360	-0.098	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061217 vs STAU2 — BRCA

Explore this scatter interactively →