Regulation of mesonephros development

Across TCGA patient cohorts, RNA activity of the Regulation of mesonephros development pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INSYN1, ZC2HC1C, and DDAH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mesonephros development activity versus INSYN1 in HNSC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	INSYN1 →	+0.584	+0.258	.001	.008	3	5
CCRCC	ZC2HC1C →	+0.243	+0.613	.005	.001	3	5
CCRCC	DDAH1 →	+0.604	+0.473	<.001	.002	3	5
BRCA	ERBB4 →	+1.967	+0.754	<.001	<.001	3	4
BRCA	PDK2 →	+0.504	+0.452	.002	.001	3	4
CCRCC	FAAH →	+0.488	+0.541	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061217 vs INSYN1 — HNSC

Explore this scatter interactively →