Regulation of mesonephros development

Across TCGA cell cohorts, RNA activity of the Regulation of mesonephros development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPTBN4, MYO10, and ZNF45, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPTBN4 grouped by Regulation of mesonephros development-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SPTBN4 →	-0.607	-1.216	.005	.008	2	4
SKIN	MYO10 →	-1.347	-1.006	.001	.009	3	3
BREAST	ZNF45 →	+0.895	+0.662	.008	.007	2	4
BREAST	ADGRV1 →	+1.713	+0.676	<.001	.001	3	3
BREAST	RTL8B →	+1.231	+0.422	.001	.009	3	3
BREAST	RNF208 →	+1.404	+0.633	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPTBN4 by Regulation of mesonephros development activity — BLOOD_Myeloma

Explore this box plot interactively →