Regulation of mesonephros development

Across TCGA cell cohorts, RNA activity of the Regulation of mesonephros development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGSM3, PMM1, and PSMA6, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SGSM3 grouped by Regulation of mesonephros development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SGSM3 →	+0.206	+1.795	.003	<.001	3	1
BREAST	PMM1 →	+0.403	+1.795	.001	<.001	3	1
BREAST	PSMA6 →	-0.693	-1.795	.001	<.001	3	1
BREAST	SPIN1 →	+0.330	+1.795	.004	<.001	3	1
BREAST	EDF1 →	-0.300	-1.795	.005	<.001	3	1
BREAST	KRT37 →	-0.220	-1.795	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SGSM3 by Regulation of mesonephros development activity — BREAST

Explore this box plot interactively →