Regulation of mesonephros development

Across TCGA cell cohorts, RNA activity of the Regulation of mesonephros development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMA3, PRORP, and EMC9, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mesonephros development activity versus PSMA3 in BREAST (Pearson r = 0.96).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PSMA3 →	+0.669	+1.795	.006	<.001	3	1
BREAST	PRORP →	+1.009	+1.795	.001	<.001	3	1
BREAST	EMC9 →	+1.296	+1.795	.004	<.001	3	1
BREAST	FERMT1 →	-2.575	-1.807	.001	.004	3	1
BREAST	MAP1LC3A →	-3.373	-1.795	.005	<.001	3	1
BREAST	MAGED2 →	-0.653	-1.795	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061217 vs PSMA3 — BREAST

Explore this scatter interactively →