Fungiform papilla morphogenesis

Across TCGA patient cohorts, RNA activity of the Fungiform papilla morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANKFY1, ZNF318, and DHX40, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fungiform papilla morphogenesis activity versus ANKFY1 in LSCC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANKFY1 →	-0.218	-0.112	<.001	<.001	2	7
HNSC	ZNF318 →	+0.232	+0.070	<.001	.005	3	6
HNSC	DHX40 →	+0.348	+0.073	.002	.003	3	6
LSCC	LACTB →	-0.444	-0.131	<.001	<.001	3	6
LSCC	ARPC2 →	-0.292	-0.133	<.001	<.001	3	5
BRCA	S100A10 →	-0.678	-0.079	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061197 vs ANKFY1 — LSCC

Explore this scatter interactively →