Fungiform papilla morphogenesis

Across TCGA patient cohorts, RNA activity of the Fungiform papilla morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, RPEP3, and ALDH1L2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fungiform papilla morphogenesis activity versus CNRIP1 in HNSC (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CNRIP1 →	-0.536	-0.182	<.001	<.001	3	5
PDAC	RPEP3 →	+0.305	+0.185	.001	.001	3	4
HNSC	ALDH1L2 →	-0.484	-0.133	.003	.003	3	4
HNSC	DNA2 →	+0.577	+0.180	.004	<.001	3	4
HNSC	SMARCD3 →	-0.720	-0.158	.001	.004	3	4
LUAD	DHRS11 →	+0.411	+0.122	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061197 vs CNRIP1 — HNSC

Explore this scatter interactively →