Fungiform papilla morphogenesis

Across TCGA cell cohorts, RNA activity of the Fungiform papilla morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDM12, AMT, and PUS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRDM12 grouped by Fungiform papilla morphogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRDM12 →	-0.099	-0.878	.007	.003	2	5
BLOOD_Myeloma	AMT →	+0.918	+1.361	.001	.001	2	4
BLOOD_Myeloma	PUS1 →	-0.712	-1.962	.008	<.001	3	3
BLOOD_Myeloma	SP100 →	+0.828	+2.054	.003	<.001	3	3
LUNG_NSCLC_LUSC	DHODH →	-0.665	-1.261	.005	.004	3	3
BONE	DDX55 →	-1.120	-1.653	.007	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRDM12 by Fungiform papilla morphogenesis activity — BREAST

Explore this box plot interactively →