Fungiform papilla development

Across TCGA patient cohorts, RNA activity of the Fungiform papilla development pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDAC2, CCL5, and SMIM8, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fungiform papilla development activity versus HDAC2 in UVM (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	HDAC2 →	+0.714	+0.048	<.001	<.001	3	24
SARC	CCL5 →	-1.898	-0.065	<.001	<.001	2	25
UVM	SMIM8 →	+0.706	+0.075	<.001	<.001	3	23
LAML	PSTPIP1 →	-1.247	-0.105	<.001	<.001	3	23
SARC	LTB →	-1.610	-0.071	<.001	<.001	3	23
THYM	HCST →	-0.942	-0.046	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061196 vs HDAC2 — UVM

Explore this scatter interactively →