Fungiform papilla development

Across TCGA cell cohorts, RNA activity of the Fungiform papilla development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBXN7, RAD54L, and SLC41A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fungiform papilla development activity versus UBXN7 in BLOOD_Leukemia (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UBXN7 →	+0.819	+1.297	.003	<.001	3	4
BLOOD_Leukemia	RAD54L →	+0.968	+1.198	.003	.001	3	3
LUNG_SCLC	SLC41A3 →	+0.562	+0.900	.004	.002	3	3
LUNG_SCLC	ALMS1 →	+0.982	+1.149	<.001	.002	3	3
LUNG_SCLC	CCNE2 →	+1.785	+1.086	<.001	.003	3	3
LUNG_SCLC	KIFC1 →	+0.629	+1.142	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061196 vs UBXN7 — BLOOD_Leukemia

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