Regulation of chondrocyte development

Across TCGA patient cohorts, RNA activity of the Regulation of chondrocyte development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINH1, COL12A1, and PUS7L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chondrocyte development activity versus SERPINH1 in BRCA (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINH1 →	+0.833	+0.222	.008	.001	3	4
LSCC	COL12A1 →	+1.254	+0.660	<.001	.001	3	4
LUAD	PUS7L →	-0.491	-0.484	.003	.009	3	4
LUAD	WTIP →	+0.709	+0.674	.006	.004	3	4
COAD	MOB4 →	-0.305	-0.215	.006	.005	3	3
BRCA	SYDE1 →	+0.882	+0.176	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061181 vs SERPINH1 — BRCA

Explore this scatter interactively →