Regulation of insulin secretion involved in cellular response to glucose stimulus

Across TCGA patient cohorts, RNA activity of the Regulation of insulin secretion involved in cellular response to glucose stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LIN7C, RPL5, and RRP1B_S513, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of insulin secretion involved in cellular response to glucose stimulus activity versus LIN7C in PDAC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LIN7C →	+0.201	+0.029	<.001	<.001	3	5
GBM	RPL5 →	-0.302	-0.051	<.001	<.001	3	5
BRCA	RRP1B_S513 →	-1.123	-0.034	.007	.001	3	5
OV	XRCC6_T455 →	-0.609	-0.018	.001	.006	3	5
LUAD	CCDC127 →	+0.252	+0.026	<.001	.001	3	5
GBM	DDAH1 →	+0.484	+0.042	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061178 vs LIN7C — PDAC

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